Insight into oral amphiphilic cyclodextrin nanoparticles for colorectal cancer: comprehensive mathematical model of drug release kinetic studies and antitumoral efficacy in 3D spheroid colon tumors

• Sedat Ünal,
• Gamze Varan,
• Juan M. Benito,
• Yeşim Aktaş and
• Erem Bilensoy

Beilstein J. Org. Chem. 2023, 19, 139–157, doi:10.3762/bjoc.19.14

• cancer; camptothecin; 3D spheroid; cyclodextrin; oral nanoparticle; release kinetics; Introduction Cancer is still one of the most common, highly variable and fatal diseases worldwide. Therefore, studies are continuing to develop effective/innovative and more flexible treatments for various types of

• the treatment of CRC should be examined comprehensively and in detail, and each past study should shed light on possible future studies. In this study, 3D spheroid tumor models were studied to further elucidate the information we obtained in previous studies, and also mathematical release kinetic

Post-functionalization of drug-loaded nanoparticles prepared by polymerization-induced self-assembly (PISA) with mitochondria targeting ligands

• Janina-Miriam Noy,
• Fan Chen and
• Martina Stenzel

Beilstein J. Org. Chem. 2021, 17, 2302–2314, doi:10.3762/bjoc.17.148

• mitochondria target containing nanoparticles PPM-NP4-TPP and MPM-NP2-TPP were further analysed using 3D spheroid tumour models [47]. The samples were incubated with 143B and SW982 cells and the penetration profiles of the micelles were investigated using laser scanning confocal microscopy. After 3 hours of